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Article

Premature Luteinization and Cumulus Cell Defects in Ovarian-Specific <i>Smad4</i> Knockout Mice

2 Mar 2006

Abstract excerpt

SMAD4 is a central component of the TGFbeta superfamily signaling pathway. Within the ovary, TGFbeta-related proteins play crucial roles in controlling granulosa cell growth, differentiation, and steroidogenesis. To study the in vivo roles of SMAD4 during follicle development, we generated an ovarian conditional knockout of Smad4 using the cre/loxP recombination system. Smad4 ovarian-specific knockout mice are...

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PMID: 16513794
DOI: 10.1210/me.2005-0462

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