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Article

Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.

Molecular and cellular biology - 1 Jan 2008

Pangas Stephanie A, Li Xiaohui, Umans Lieve, Zwijsen An, Huylebroeck Danny, Gutierrez Carolina, Wang Degang, Martin James F, Jamin Soazik P, Behringer Richard R, Robertson Elizabeth J, Matzuk Martin M

Abstract excerpt

The transforming growth factor beta (TGFbeta) family has critical roles in the regulation of fertility. In addition, the pathogenesis of some human cancers is attributed to misregulation of TGFbeta function and SMAD2 or SMAD4 mutations. There are limited mouse models for the BMP signaling SMADs (BR-SMADs) 1, 5, and 8 because of embryonic lethality and suspected genetic redundancy. Using tissue-specific ablation...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17967875
DOI: 10.1128/MCB.01404-07
PMCID: PMC2223289

Genes

SMAD2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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