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Article

Regulatory roles of transforming growth factor beta family members in folliculogenesis

20 Jul 2009

Abstract excerpt

Bidirectional signaling between the oocyte and surrounding somatic cells is absolutely essential for successful germ cell development in mammals. Oocytes secrete proteins that are necessary for granulosa cells growth and differentiation, whilst granulosa cells regulate oocyte development and integrate ovarian function with the rest of the body by orchestrating gonadal steroidogenesis. The importance of...

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PMID: 20836015
DOI: 10.1002/wsbm.21

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