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Oocyte-Specific Knockout: A Novel In Vivo Approach for Studying Gene Functions During Folliculogenesis, Oocyte Maturation, Fertilization, and Embryogenesis1

28 Aug 2008

Abstract excerpt

Knockout mice have been highly useful tools in helping to understand the functional roles of specific genes in development and diseases. However, in many cases, knockout mice are embryonic lethal, which prevents investigation into a number of important questions, or they display developmental abnormalities, including fertility defects. In contrast, conditional knockout, which is achieved by the Cre-LoxP system,...

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PMID: 18753607
DOI: 10.1095/biolreprod.108.070409

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