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Article

Ovarian Follicle Development Requires Smad3

15 Jun 2004

Abstract excerpt

Smad3 is an important mediator of the TGF beta signaling pathway. Interestingly, Smad3-deficient (Smad3-/-) mice have reduced fertility compared with wild-type (WT) mice. To better understand the molecular mechanisms underlying the reduced fertility in Smad3-/- animals, this work tested the hypothesis that Smad3 deficiency interferes with three critical aspects of folliculogenesis: growth, atresia, and...

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Identifiers

PMID: 15192076
DOI: 10.1210/me.2003-0414

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