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Article

Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells.

Biology of reproduction - 1 Dec 2008

Pelusi Carla, Ikeda Yayoi, Zubair Mohamad, Parker Keith L

Abstract excerpt

The nuclear receptor steroidogenic factor 1 (SF-1 [officially designated NR5A1]) is essential for fetal gonadal development, but its roles in postnatal ovarian function are less well defined. Herein, we have extended our analyses of knockout (KO) mice with markedly decreased SF-1 expression in granulosa cells. As described, these SF-1 KO mice had hypoplastic ovaries that contained a decreased number of follicles...

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Identifiers

PMID: 18703422
DOI: 10.1095/biolreprod.108.069435
PMCID: PMC2780474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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