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Article

Connective Tissue Growth Factor Is Required for Normal Follicle Development and Ovulation

26 Aug 2011

Abstract excerpt

Connective tissue growth factor (CTGF) is a cysteine-rich protein the synthesis and secretion of which are hypothesized to be selectively regulated by activins and other members of the TGF-β superfamily. To investigate the in vivo roles of CTGF in female reproduction, we generated Ctgf ovarian and uterine conditional knockout (cKO) mice. Ctgf cKO mice exhibit severe subfertility and multiple reproductive defects...

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Identifiers

PMID: 21868453
DOI: 10.1210/me.2011-1045

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