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Minimal Fertility Defects in Mice Deficient in Oocyte-Expressed Smad41

8 Sept 2011

Abstract excerpt

Bidirectional signaling between oocytes and granulosa cells is required for normal folliculogenesis. Oocyte-secreted members of the transforming growth factor beta (TGFB) family, growth differentiation factor 9 (GDF9), and bone morphogenetic protein 15 (BMP15) are well-known mediators of granulosa cell function. Deletion in granulosa cells of Smad4, the common SMAD mediating all canonical TGFB-related protein...

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PMID: 21900682
DOI: 10.1095/biolreprod.111.094375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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