Article
Oocyte-derived Smad4 is not required for development of the oocyte or the preimplantation embryo.
Theriogenology - 15 Mar 2015
Kaune Heidy, Peyrache Emeline, Williams Suzannah A
Abstract excerpt
UNLABELLED: The generation of a competent egg requires complex molecular interactions between the oocyte and the ovary, and transforming growth factor β (TGF-β) is a major signaling pathway. Smad4 is a central regulator of the TGF-β signaling pathway as it mediates gene expression triggered by activation of TGF-β receptors. Deletion of Smad4 in granulosa cells disrupts follicle development; however, the role of...
Topics
- Alleles
- Animals
- Blastocyst
- Female
- Gene Deletion
- Gene Expression Regulation, Developmental
- Genotype
- Male
- Mice
- Oocytes
- Smad4 Protein