Article
Rolling blackout is required for synaptic vesicle exocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 2006
Huang Fu-De, Woodruff Elvin, Mohrmann Ralf, Broadie Kendal
Abstract excerpt
Rolling blackout (RBO) is a putative transmembrane lipase required for phospholipase C-dependent phosphatidylinositol 4,5-bisphosphate-diacylglycerol signaling in Drosophila neurons. Conditional temperature-sensitive (TS) rbo mutants display complete, reversible paralysis within minutes, demonstrating that RBO is acutely required for movement. RBO protein is localized predominantly in presynaptic boutons at...
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