Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.

doi:10.1016/s0896-6273(03)00088-6

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Article

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.

Neuron - 6 Mar 2003

Altrock Wilko D, tom Dieck Susanne, Sokolov Maxim, Meyer Alexander C, Sigler Albrecht, Brakebusch Cord, Fässler Reinhard, Richter Karin, Boeckers Tobias M, Potschka Heidrun, Brandt Claudia, Löscher Wolfgang, Grimberg Dörte, Dresbach Thomas, Hempelmann Anne, Hassan Hadir, Balschun Detlef, Frey Julietta U, Brandstätter Johann H, Garner Craig C, Rosenmund Christian, Gundelfinger Eckart D

Abstract excerpt

Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic...

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PMID: 12628169
DOI: 10.1016/s0896-6273(03)00088-6

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