Article
Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release.
Cell - 5 Apr 2002
Verstreken Patrik, Kjaerulff Ole, Lloyd Thomas E, Atkinson Richard, Zhou Yi, Meinertzhagen Ian A, Bellen Hugo J
Abstract excerpt
We have identified mutations in Drosophila endophilin to study its function in vivo. Endophilin is required presynaptically at the neuromuscular junction, and absence of Endophilin dramatically impairs endocytosis in vivo. Mutant larvae that lack Endophilin fail to take up FM1-43 dye in synaptic boutons, indicating an inability to retrieve synaptic membrane. This defect is accompanied by an expansion of the...
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