Article
CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations.
Journal of bone and mineral metabolism - 1 Jan 2006
Huang Qing-Yang, Shen Hui, Deng Hong-Yi, Conway Theresa, Elze Leo, Davies K Michael, Recker Robert R, Deng Hong-Wen
Abstract excerpt
Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in osteoporosis. In this study, we conducted linkage and association tests between the CA repeat...
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