Article
Osteopenia in 37 members of seven families: analysis based on a model of dominant inheritance.
Molecular medicine (Cambridge, Mass.) - 1 May 1996
Spotila L D, Caminis J, Devoto M, Shimoya K, Sereda L, Ott J, Whyte M P, Tenenhouse A, Prockop D J
Abstract excerpt
BACKGROUND: The genetic factors involved in determining bone mineral density (BMD) have not been fully elucidated. We have begun genetic linkage analysis of seven families in which many members are osteopenic, in order to identify chromosomal loci that are potentially involved in determining BMD. MATERIALS AND METHODS: Spine BMD was measured in 143 members of seven kindred with familial osteopenia. The absolute...
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