Article
Association of a polymorphism in the TNFR2 gene with low bone mineral density.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2000
Spotila L D, Rodriguez H, Koch M, Adams K, Caminis J, Tenenhouse H S, Tenenhouse A
Abstract excerpt
Previous genetic linkage data suggested that a gene on chromosome 1p36.2-36.3 might be linked to low bone mineral density (BMD). Here, we examine the gene for tumor necrosis factor receptor 2 (TNFR2), a candidate gene within that interval, for association with low BMD in a group of 159 unrelated individuals. We assess two polymorphic sites within the gene, a microsatellite repeat within intron 4, and a...
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