Article
Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear families.
Bone - 1 Aug 2004
Zhao Lan-Juan, Liu Peng-Yuan, Long Ji-Rong, Lu Yan, Xu Fu-Hua, Zhang Yuan-Yuan, Shen Hui, Xiao Peng, Elze Leo, Recker Robert R, Deng Hong-Wen
Abstract excerpt
Extensive studies have been performed on the association between the estrogen receptor alpha (ER-alpha) gene and bone mineral density (BMD). Despite considerable efforts, the studies using limited markers and relatively small sample size have yielded largely inconsistent results. In this study, 1873 Caucasian subjects from 405 nuclear families containing 1512 sib pairs were recruited. BMD at the lumbar spine (LS)...
Topics
- Absorptiometry, Photon
- Adult
- Aged
- Base Sequence
- Bone Density
- DNA Primers
- Estrogen Receptor alpha
- Female
- Genetic Linkage
- Haplotypes
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide