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No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women.

Bone - 1 Apr 2005

Jiang De-Ke, Shen Hui, Li Miao-Xin, Jiang Cheng, Yang Na, Zhu Jie, Wu Yong, Qin Yue-Juan, Zhou Qi, Deng Hong-Wen

Abstract excerpt

Osteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). BMD is a complex trait that is determined by multiple genes. Insulin-like growth factor I (IGF-I) is an important growth factor of bone and thus IGF-I gene has been considered as an attractive candidate gene for osteoporosis. A few studies on the relationship between variants of the IGF-I gene and BMD variation,...

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PMID: 15780973
DOI: 10.1016/j.bone.2005.01.013

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