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Article

Shear stress induces hepatocytePAI-1gene expression through cooperative Sp1/Ets-1 activation of transcription

25 Feb 2006

Abstract excerpt

Partial hepatectomy causes hemodynamic changes that increase portal blood flow in the remaining lobe, where the expression of immediate-early genes, including plasminogen activator inhibitor-1 (PAI-1), is induced. We hypothesized that a hyperdynamic circulatory state occurring in the remaining lobe induces immediate-early gene expression. In this study, we investigated whether the mechanical force generated by...

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PMID: 16500919
DOI: 10.1152/ajpgi.00467.2005

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