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Article

Structural and functional insights into the B30.2/SPRY domain.

The EMBO journal - 22 Mar 2006

Woo Jae-Sung, Imm Joon-Hyuk, Min Chang-Ki, Kim Kyung-Jin, Cha Sun-Shin, Oh Byung-Ha

Abstract excerpt

The B30.2/SPRY domain is present in approximately 700 eukaryotic (approximately 150 human) proteins, including medically important proteins such as TRIM5alpha and Pyrin. Nonetheless, the functional role of this modular domain remained unclear. Here, we report the crystal structure of an SPRY-SOCS box family protein GUSTAVUS in complex with Elongins B and C, revealing a highly distorted two-layered beta-sandwich...

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Identifiers

PMID: 16498413
DOI: 10.1038/sj.emboj.7600994
PMCID: PMC1422157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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