Article
The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues.
Nature structural & molecular biology - 1 Jan 2006
Masters Seth L, Yao Shenggen, Willson Tracy A, Zhang Jian-Guo, Palmer Kirsten R, Smith Brian J, Babon Jeffrey J, Nicola Nicos A, Norton Raymond S, Nicholson Sandra E
Abstract excerpt
The four mammalian SPRY domain-containing SOCS box proteins (SSB-1 to SSB-4) are characterized by a C-terminal SOCS box and a central SPRY domain. We have determined the first SPRY-domain structure, as part of SSB-2, by NMR. This domain adopts a novel fold consisting of a beta-sandwich structure...
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