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Article

Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence?

7 Oct 2005

Abstract excerpt

SPRY and B30.2 are homologous domains which can be identified in 11 protein families encoded in the human genome. These include cell surface receptors of the immunoglobulin super-family (BTNs), negative regulators of the JAK/STAT pathway (SOCS-box SSB1-4) and proteins encoded by the numerous TRIM genes. Collectively, proteins containing SPRY and B30.2 domains cover a wide range of functions, including regulation...

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Identifiers

PMID: 16313355
DOI: 10.1111/j.1365-2567.2005.02248.x

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