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Article

Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase.

Nature communications - 10 Jun 2019

Kung Wei-Wei, Ramachandran Sarath, Makukhin Nikolai, Bruno Elvira, Ciulli Alessio

Abstract excerpt

The suppressor of cytokine signaling 2 (SOCS2) acts as substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex. SOCS2 binds to phosphotyrosine-modified epitopes as degrons for ubiquitination and proteasomal degradation, yet the molecular basis of substrate recognition has remained elusive. Here, we report co-crystal structures of SOCS2-ElonginB-ElonginC in complex with phosphorylated peptides from...

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Share to Crystallography, X-Ray
Share to Phosphotyrosine
Share to Receptors, Erythropoietin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Somatotropin

Share to Substrate Specificity

Share to Suppressor of Cytokine Signaling Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 31182716
DOI: 10.1038/s41467-019-10190-4
PMCID: PMC6557900

Genes

SOCS2
GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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