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Article

Structural insights into SorCS2-Nerve Growth Factor complex formation.

Nature communications - 30 Jul 2018

Leloup Nadia, Chataigner Lucas M P, Janssen Bert J C

Abstract excerpt

Signaling of SorCS receptors by proneurotrophin ligands regulates neuronal plasticity, induces apoptosis and is associated with mental disorders. The detailed structure of SorCS2 and its extracellular specificity are unresolved. Here we report crystal structures of the SorCS2-NGF complex and unliganded SorCS2 ectodomain, revealing cross-braced SorCS2 homodimers with two NGF dimers bound in a 2:4 stoichiometry....

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Source

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Identifiers

PMID: 30061605
DOI: 10.1038/s41467-018-05405-z
PMCID: PMC6065357

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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