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Advances in the Structural Understanding of Vif Proteins

1 Mar 2008

Abstract excerpt

The multidomain HIV-1 Vif protein recruits several cellular partners to achieve neutralization of the antiviral activity of APOBEC3 proteins. Vif neutralizes APOBEC3G and APOBEC3F predominantly by forming an E3 ubiquitin ligase with Cullin5, ElonginB and ElonginC that targets these proteins for degradation by the ubiquitin-proteasome pathway. Vif associates with the Cullin5-ElonginB-ElonginC complex by binding...

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PMID: 18336256
DOI: 10.2174/157016208783885056

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Advances in the Structural Understanding of Vif ProteinsPMID 18336256Read ↗

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