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Article

The adenovirus L4 100-kilodalton protein is necessary for efficient translation of viral late mRNA species.

Journal of virology - 1 Jun 1990

Hayes B W, Telling G C, Myat M M, Williams J F, Flint S J

Abstract excerpt

When screening a number of adenovirus type 5 (Ad5) temperature-sensitive mutants for defects in viral gene expression, we observed that H5ts1-infected 293 cells accumulated reduced levels of newly synthesized viral late proteins. Pulse-labeling and pulse-chase experiments were used to establish that the late proteins synthesized in H5ts1-infected cells under nonpermissive conditions were as stable as those made...

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Identifiers

PMID: 2335816
DOI: 10.1128/JVI.64.6.2732-2742.1990
PMCID: PMC249453

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