The adenovirus L4 100-kilodalton protein is necessary for efficient translation of viral late mRNA species.

doi:10.1128/JVI.64.6.2732-2742.1990

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Article

The adenovirus L4 100-kilodalton protein is necessary for efficient translation of viral late mRNA species.

Journal of virology - 1 Jun 1990

Hayes B W, Telling G C, Myat M M, Williams J F, Flint S J

Abstract excerpt

When screening a number of adenovirus type 5 (Ad5) temperature-sensitive mutants for defects in viral gene expression, we observed that H5ts1-infected 293 cells accumulated reduced levels of newly synthesized viral late proteins. Pulse-labeling and pulse-chase experiments were used to establish that the late proteins synthesized in H5ts1-infected cells under nonpermissive conditions were as stable as those made...

Topics

Adenoviruses, Human
Amino Acid Sequence
Base Sequence
Cell Line
DNA, Viral
Eukaryotic Initiation Factor-2
HeLa Cells
Humans
KB Cells
Kinetics
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Weight

Mutation

Phosphorylation

Polyribosomes

Protein Binding

Protein Biosynthesis

RNA, Messenger

Source

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Identifiers

PMID: 2335816
DOI: 10.1128/JVI.64.6.2732-2742.1990
PMCID: PMC249453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2335816-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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