Genetic analysis of the vaccinia virus I6 telomere-binding protein uncovers a key role in genome encapsidation.

doi:10.1128/jvi.77.20.10929-10942.2003

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Article

Genetic analysis of the vaccinia virus I6 telomere-binding protein uncovers a key role in genome encapsidation.

Journal of virology - 1 Oct 2003

Grubisha Olivera, Traktman Paula

Abstract excerpt

The linear, double-stranded DNA genome of vaccinia virus contains covalently closed hairpin termini. These hairpin termini comprise a terminal loop and an A+T-rich duplex stem that has 12 extrahelical bases. DeMasi et al. have shown previously that proteins present in infected cells and in virions form distinct complexes with the telomeric hairpins and that these interactions require the extrahelical bases. The...

Topics

Alleles
Amino Acid Sequence
DNA, Viral
Genome, Viral
Molecular Sequence Data
Morphogenesis
Phenotype
Telomere-Binding Proteins
Vaccinia virus
Viral Core Proteins
Viral Proteins
Virus Assembly

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Identifiers

PMID: 14512543
DOI: 10.1128/jvi.77.20.10929-10942.2003
PMCID: PMC225002

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