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Article

Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2006

Xiong Shunbin, Van Pelt Carolyn S, Elizondo-Fraire Ana C, Liu Geng, Lozano Guillermina

Abstract excerpt

Loss of Mdm2 or Mdm4 leads to embryo lethal phenotypes that are p53-dependent. To determine whether Mdm2 and Mdm4 inhibit p53 function redundantly in a more restricted cell type, conditional alleles were crossed to a neuronal specific Cre transgene to delete Mdm2 and Mdm4 in the CNS. Mice lacking Mdm2 in the CNS developed hydranencephaly at embryonic day 12.5 due to apoptosis, whereas Mdm4 deletion showed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-mdm2

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Source

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Identifiers

PMID: 16492743
DOI: 10.1073/pnas.0508500103
PMCID: PMC1413885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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