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Article

Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

Molecular and cellular biology - 1 Jan 2006

Grier Jason D, Xiong Shunbin, Elizondo-Fraire Ana C, Parant John M, Lozano Guillermina

Abstract excerpt

The function of the p53 tumor suppressor to inhibit proliferation or initiate apoptosis is often abrogated in tumor cells. Mdm2 and its homolog, Mdm4, are critical inhibitors of p53 that are often overexpressed in human tumors. In mice, loss of Mdm2 or Mdm4 leads to embryonic lethal phenotypes that are completely rescued by concomitant loss of p53. To examine the role of Mdm2 and Mdm4 in a temporal and...

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Share to Embryo, Mammalian
Share to Embryonic Development
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Myocytes, Cardiac

Share to Proto-Oncogene Proteins c-mdm2

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Source

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Identifiers

PMID: 16354690
DOI: 10.1128/MCB.26.1.192-198.2006
PMCID: PMC1317622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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