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Article

Characterization of HSD17B1 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer.

The Journal of steroid biochemistry and molecular biology - 1 Mar 2008

Plourde Marie, Samson Carolle, Durocher Francine, Sinilnokova Olga, Simard Jacques

Abstract excerpt

A family history of disease and estrogen exposure are risk factors for breast cancer. The HSD17B1 gene encodes a key steroidogenic enzyme that catalyses the final step of estradiol biosynthesis, rendering it a good candidate gene for breast cancer susceptibility. The current study was designed to screen for HSD17B1 germline mutations potentially involved in breast cancer susceptibility. DNA samples from 50...

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Source

Identifiers

PMID: 18083510
DOI: 10.1016/j.jsbmb.2007.10.004

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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