Characterization of HSD17B1 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer.

doi:10.1016/j.jsbmb.2007.10.004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Characterization of HSD17B1 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer.

The Journal of steroid biochemistry and molecular biology - 1 Mar 2008

Plourde Marie, Samson Carolle, Durocher Francine, Sinilnokova Olga, Simard Jacques

Abstract excerpt

A family history of disease and estrogen exposure are risk factors for breast cancer. The HSD17B1 gene encodes a key steroidogenic enzyme that catalyses the final step of estradiol biosynthesis, rendering it a good candidate gene for breast cancer susceptibility. The current study was designed to screen for HSD17B1 germline mutations potentially involved in breast cancer susceptibility. DNA samples from 50...

Topics

11-beta-Hydroxysteroid Dehydrogenase Type 1
Adult
Amino Acid Substitution
Base Sequence
Breast Neoplasms
Canada
Cell Line
DNA Primers
Female
France
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Germ-Line Mutation

Haplotypes

Humans

Linkage Disequilibrium

Middle Aged

Mutagenesis, Site-Directed

Source

Open in PubMed

Identifiers

PMID: 18083510
DOI: 10.1016/j.jsbmb.2007.10.004

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of HSD17B1 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer.PMID 18083510Read ↗

Mutation analysis and characterization of HSD17B2 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer.Semantic proximity Read ↗

Analysis of 17beta-hydroxysteroid dehydrogenase types 5, 7, and 12 genetic sequence variants in breast cancer cases from French Canadian Families with high risk of breast and ovarian cancer.Semantic proximity Read ↗

Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies.Semantic proximity Read ↗

A new polymorphism in the coding region of exon four in HSD17B2 in relation to risk of sporadic and hereditary breast cancer.Semantic proximity Read ↗

HSD17B1 gene polymorphisms and risk of endometrial and breast cancer.Semantic proximity Read ↗

HSD17B1 genetic variants and hormone receptor-defined breast cancer.Semantic proximity Read ↗

Human 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics.Semantic proximity Read ↗

Genetic variation in the HSD17B1 gene and risk of prostate cancer.Semantic proximity Read ↗

Polymorphism of HSD17B1 Ser312Gly with Cancer Risk: Evidence from 66,147 Subjects.Semantic proximity Read ↗

Impact of functional germline variants and a deletion polymorphism in APOBEC3A and APOBEC3B on breast cancer risk and survival in a Swedish study population.Semantic proximity Read ↗

In silico analysis of nsSNPs in CYP19A1 gene affecting breast cancer associated aromatase enzyme.Semantic proximity Read ↗

The association between HSD17B1 Ser312Gly polymorphism and breast cancer risk: a meta-analysis including 31,053 subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.