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Article

The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy.

European urology - 1 Jul 2012

Audet-Walsh Étienne, Bellemare Judith, Lacombe Louis, Fradet Yves, Fradet Vincent, Douville Pierre, Guillemette Chantal, Lévesque Éric

Abstract excerpt

BACKGROUND: The relationship between polymorphisms in the hydroxysteroid (17-beta) dehydrogenase (HSD17B) family of genes, which are involved in steroid hormone biotransformation, and the risk of prostate cancer (PCa) progression remains unexplored. OBJECTIVE: Determine whether inherited variations in HSD17B genes are associated with PCa progression. DESIGN, SETTING, AND PARTICIPANTS: We studied two independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22209174
DOI: 10.1016/j.eururo.2011.12.021

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