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Article

Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk.

Gynecologic oncology - 1 Apr 2011

Karageorgi Stalo, McGrath Monica, Lee I-Min, Buring Julie, Kraft Peter, De Vivo Immaculata

Abstract excerpt

OBJECTIVE: Hydroxysteroid-dehydrogenase-17b (HSD17b) genes control the last step in estrogen biosynthesis. The isoenzymes HSD17b2 and HSD17b4 in the uterus preferentially catalyze the conversion of estradiol, the most potent and active form of estrogen, to estrone, the inactive form of estrogen. Endometrial adenocarcinoma is linked to excessive exposure to estrogens. We hypothesized that single nucleotide...

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Identifiers

PMID: 21129770
DOI: 10.1016/j.ygyno.2010.11.014
PMCID: PMC3062639

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NHS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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