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Article

Interference with topoisomerase IIalpha potentiates melphalan cytotoxicity.

International journal of oncology - 1 Feb 2002

Hirota Haruyo, Gosky David, Berger Nathan A, Chatterjee Satadal

Abstract excerpt

We studied the consequences of interfering with DNA topoisomerase IIalpha (topo IIalpha) activity on melphalan-induced cytotoxicity. In order to accomplish our goal we used three different approaches to interfere with topo IIalpha. These include: i) use of three V79 Chinese hamster lung fibroblast-derived mutant cell lines, V507, V511, and V513 that are dysfunctional in topo IIalpha activity; ii) treatment of...

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PMID: 11788894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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