Differential toxicity of 3-aminobenzamide to wild-type and 6-thioguanine-resistant Chinese hamster cells by interference with pathways of purine biosynthesis.

doi:10.1016/0167-8817(84)90051-8

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Article

Differential toxicity of 3-aminobenzamide to wild-type and 6-thioguanine-resistant Chinese hamster cells by interference with pathways of purine biosynthesis.

Mutation research - 1 Jan 2000

Cleaver J E

Abstract excerpt

3-Aminobenzamide is commonly assumed to be a specific inhibitor of poly(ADP-ribose) polymerase. However, it also inhibits de novo synthesis of DNA purines at concentrations of 5 mM and above. A mutant cell line that lacks the ability to incorporate exogenous purines is therefore exceptionally sen...

Topics

Animals
Benzamides
Cell Line
Cricetinae
Cricetulus
DNA Replication
Drug Resistance
Female
Kinetics
Mutation
Nucleoproteins
Ovary
Thioguanine

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