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Article

The effect of thymidine on the induction of micronuclei by alkylating agents in V79 Chinese hamster cells.

Mutation research - 1 Jan 2000

Bonatti S, Simi L, Abbondandolo A

Abstract excerpt

Incubation in thymidine-containing medium resulted in increased lethality and micronucleus frequency in V79 cells treated with ethyl nitrosourea (ENU), methyl nitrosourea (MNU) and ethyl methane-sulphonate (EMS) but not with methyl methanesulfonate (MMS). Thymidine had no effect in ENU treated HeLa cells. In V79 cells, the presence of thymidine during post-treatment DNA replication was necessary for the effect....

Topics

Alkylating Agents
Animals
Cell Nucleus
Cell Survival
Chromosome Aberrations
Cricetinae
Cricetulus
DNA
Dose-Response Relationship, Drug
Guanine
Mutation
Thymidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 4000162
DOI: 10.1016/0027-5107(85)90131-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-4000162-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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