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Article

Mechanism of epipodophyllotoxin-induced cell death in poly(adenosine diphosphate-ribose) synthesis-deficient V79 Chinese hamster cell lines.

Cancer research - 1 May 1990

Chatterjee S, Trivedi D, Petzold S J, Berger N A

Abstract excerpt

Mutant Chinese hamster V79 cells selected for alterations in poly(ADP-ribose) metabolism were shown to be resistant to epipodophyllotoxin (VP-16)-induced cytotoxicity. Cell lines ADPRT 54 and ADPRT 351 have reduced activity of poly(ADP-ribose) polymerase. N2, N3, and N4 cell lines grow in the absence of nicotinamide, with total NAD levels 1.5-3% of those found in parental V79 cells grown in complete medium. When...

Topics

Animals
Cell Line
Cell Survival
Cricetinae
DNA Damage
DNA, Single-Stranded
Etoposide
Mutation
Nucleoside Diphosphate Sugars
Poly Adenosine Diphosphate Ribose
Sister Chromatid Exchange

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PMID: 2328496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2328496-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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