Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the carbamoylation reaction in the biological activity of methyl nitrosourea.

Mutation research - 1 Aug 1990

Serebryanyi A M, Sal'nikova L E, Bakhitova L M, Paschin YuV

Abstract excerpt

Study of the mutagenic action of methyl nitrosourea (MNU) on the CHO-AT3-2 Chinese hamster cell at 2 regimes of cell treatment (a short-term regime and prolonged 1-h treatment) revealed that increase in the duration of treatment enhanced both cell lethality and clastogenic and mutagenic effects at the TK locus and did not influence the mutation frequency at the OUAr locus. On the basis of kinetic considerations...

Topics

Alkylation
Animals
Benzopyrenes
Cell Line
Cell Survival
Cricetinae
Cyanates
DNA
Dose-Response Relationship, Drug
Drug Resistance
Ethyl Methanesulfonate
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylnitrosourea

Mutagenicity Tests

Mutation

Ouabain

Source

Identifiers

PMID: 2385238
DOI: 10.1016/0027-5107(90)90026-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2385238-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the carbamoylation reaction in the biological activity of methyl nitrosourea.PMID 2385238Read ↗

[Potassium cyanate modification of the toxic and mutagenic effects of gamma radiation and benzo(a)pyrene].Semantic proximity Read ↗

Genetic consequences of tolerance to methylation DNA damage in mammalian cells.Semantic proximity Read ↗

Multiple-endpoint mutagenesis with Chinese hamster ovary (CHO) cells: evaluation with eight carcinogenic and non-carcinogenic compounds.Semantic proximity Read ↗

Methoxyamine modification of abasic sites protects CHO cells from the cytotoxic and mutagenic effects of oxygen alkylation.Semantic proximity Read ↗

Differential effect of acetyltransferase expression on the genotoxicity of heterocyclic amines in CHO cells.Semantic proximity Read ↗

Genetic toxicity of N-methylcarbamate insecticides and their N-nitroso derivatives.Semantic proximity Read ↗

DNA repair pathways in mammalian cells analyzed by isolation of ACNU-sensitive Chinese hamster ovary cells.Semantic proximity Read ↗

Induction of mutation, sister-chromatid exchanges, and chromosome aberrations by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in Chinese hamster ovary cells.Semantic proximity Read ↗

Thiol-enhanced decomposition of MNNG, ENNG, and nitrosocimetidine: relationship to mutagenicity in V79 Chinese hamster cells.Semantic proximity Read ↗

Response of V79 cells to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) treatment: inhibition of poly(ADP-ribose) and topoisomerase activity.Semantic proximity Read ↗

Transnitrosation of non-mutagenic N-nitrosoproline forms mutagenic N-nitroso-N-methylurea.Semantic proximity Read ↗

3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) induces gene mutations and inhibits metabolic cooperation in cultured Chinese hamster cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.