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Article

The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors.

Molecular and cellular biology - 1 Mar 2006

Franco Mélanie, Furstoss Olivia, Simon Valérie, Benistant Chrsitine, Hong Wan Jing, Roche Serge

Abstract excerpt

The Src family of protein-tyrosine kinases (SFK) play important roles in mitogenesis and morphological changes induced by growth factors. The involved substrates are, however, ill defined. Using an antiphosphotyrosine antibody to screen tyrosine-phosphorylated cDNA expression library, we have identified Tom1L1, an adaptor protein of the Tom1 family and a novel substrate and activator of the SFK. Surprisingly, we...

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Identifiers

PMID: 16479011
DOI: 10.1128/MCB.26.5.1932-1947.2006
PMCID: PMC1430241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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