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Src Activation Plays an Important Key Role in Lymphomagenesis Induced by FGFR1 Fusion Kinases

22 Sept 2011

Abstract excerpt

Chromosomal translocations and activation of the fibroblast growth factor (FGF) receptor 1 (FGFR1) are a feature of stem cell leukemia-lymphoma syndrome (SCLL), an aggressive malignancy characterized by rapid transformation to acute myeloid leukemia and lymphoblastic lymphoma. It has been suggested that FGFR1 proteins lose their ability to recruit Src kinase, an important mediator of FGFR1 signaling, as a result...

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PMID: 21937681
DOI: 10.1158/0008-5472.can-11-1109

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