Article
STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction.
Immunity - 1 Apr 1997
Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K
Abstract excerpt
We previously identified a putative signal transducing adaptor molecule, named STAM, that contains an Src homology 3 (SH3) domain and immunoreceptor tyrosine-based activation motif (ITAM). In this report, we demonstrate the functional significance of STAM in cytokine-mediated signal transduction....
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Cell Division
- DNA
- Endosomal Sorting Complexes Required for Transport
- Gene Expression Regulation
- Genes, myc
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Interleukin-2
- Janus Kinase 2
- Janus Kinase 3
- Mice