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Article

Sequence of molecular genetic events in colorectal tumorigenesis.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Dec 1999

Laurent-Puig P, Blons H, Cugnenc P H

Abstract excerpt

Intensive screening for genetic alteration in colorectal cancer led to the identification of two types of colorectal tumours that are distinct by their carcinogenesis processes. The first group, named LOH (for loss of heterozygosity)-positive, is characterized by hyperploidy and allelic losses in...

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Source

Identifiers

PMID: 10772417

Genes

APC
BAX
SMAD2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10772417-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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