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Article

TRIM5 and the Regulation of HIV-1 Infectivity

30 May 2012

Abstract excerpt

The past ten years have seen an explosion of information concerning host restriction factors that inhibit the replication of HIV-1 and other retroviruses. Among these factors is TRIM5, an innate immune signaling molecule that recognizes the capsid lattice as soon as the retrovirion core is released into the cytoplasm of otherwise susceptible target cells. Recognition of the capsid lattice has several consequences...

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PMID: 22701176
DOI: 10.1155/2012/426840

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