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Article

Forced homo-oligomerization of RARalpha leads to transformation of primary hematopoietic cells.

Cancer cell - 1 Feb 2006

Kwok Colin, Zeisig Bernd B, Dong Shuo, So Chi Wai Eric

Abstract excerpt

Almost 100% of APL patients carry chimeric transcripts encoding truncated RARalpha fused to homo-oligomerization domains from partner proteins. To gain further insights into the cellular transformation mechanisms mediated by RARalpha fusion proteins, thorough structure/function analyses have been performed and identified the POZ homo-oligomerization domain as the minimal transformation domain that is necessary...

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Identifiers

PMID: 16473277
DOI: 10.1016/j.ccr.2006.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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