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Article

Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006

Zhou Jun, Pérès Laurent, Honoré Nicole, Nasr Rihab, Zhu Jun, de Thé Hugues

Abstract excerpt

The pathogenesis of acute promyelocytic leukemia involves the transcriptional repression of master genes of myeloid differentiation by the promyelocytic leukemia-retinoic acid receptor alpha (PML/RARA) oncogene. PML-enforced RARA homodimerization allows the tighter binding of corepressors, silencing RARA target genes. In addition, homodimerization dramatically extends the spectrum of DNA-binding sites of the...

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Source

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Identifiers

PMID: 16757557
DOI: 10.1073/pnas.0603324103
PMCID: PMC1474145

Genes

RARA
PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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