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Article

Dimerization: a versatile switch for oncogenesis

11 May 2004

Abstract excerpt

Forced dimerization or oligomerization has emerged as a powerful mechanism for unleashing the oncogenic properties of chimeric transcription factors in acute leukemias. Fusion of transcriptional regulators with a variety of heterologous partner proteins as a consequence of chromosomal rearrangements induces inappropriate self-association, leading to aberrant transcriptional properties and leukemogenesis. Forced...

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PMID: 15130940
DOI: 10.1182/blood-2004-03-0992

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