Article
Associations between common variation in the aromatase gene promoter region and testosterone concentrations in two young female populations.
The Journal of steroid biochemistry and molecular biology - 1 Mar 2006
Petry Clive J, Ong Ken K, Michelmore Katherine F, Artigas Soraya, Wingate Dianne L, Balen Adam H, de Zegher Francis, Ibáñez Lourdes, Dunger David B
Abstract excerpt
We recently reported association between a coding-region single nucleotide polymorphism (SNP50) in the aromatase gene that encodes a key enzyme in testosterone metabolism, with risk for the development of precocious pubarche and circulating testosterone concentrations in two independent female populations. We have now explored further association with variation in the promoter-region of the aromatase gene. We...
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