Associations between aromatase CYP19 rs10046 polymorphism and breast cancer risk: from a case-control to a meta-analysis of 20,098 subjects.

doi:10.1371/journal.pone.0053902

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Article

Associations between aromatase CYP19 rs10046 polymorphism and breast cancer risk: from a case-control to a meta-analysis of 20,098 subjects.

PloS one - 1 Jan 2013

Pineda Begoña, García-Pérez Miguel Ángel, Cano Antonio, Lluch Ana, Eroles Pilar

Abstract excerpt

Lifetime exposure to estrogen is a factor that plays an important role in the pathogenesis and progression of breast cancer. Genetic variants in genes of the biosynthesis and metabolism of estrogen have been associated with breast cancer risk. Among them, the CYP19 gene encodes for aromatase, the enzyme that catalyzes the conversion of androgens to estrogens. The rs10046 polymorphism on the CYP19 gene has been...

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PMID: 23342035
DOI: 10.1371/journal.pone.0053902
PMCID: PMC3547044

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