Article
Effect of CYP19 rs6493497 and rs7176005 haplotype status on in vivo aromatase transcription, plasma and tissue estrogen levels in postmenopausal women.
The Journal of steroid biochemistry and molecular biology - 1 Jan 2012
Straume Anne Hege, Knappskog Stian, Lønning Per Eystein
Abstract excerpt
High plasma levels of estradiol (E(2)) are correlated to increased breast cancer risk in postmenopausal women. Recently, a study reported two single nucleotide polymorphisms (SNPs) (rs6493497; C→T and rs7176005; G→A) in the aromatase (CYP19) promoter 1.1 to be associated with elevated plasma E(2) levels, most likely due to enhanced transcription. In silico predictions suggested increased transcription factor...
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