Article
Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism.
The Journal of clinical endocrinology and metabolism - 1 Jul 2003
Ibáñez Lourdes, Ong Ken K, Mongan Nigel, Jääskeläinen Jarmo, Marcos Maria Victoria, Hughes Ieuan A, De Zegher Francis, Dunger David B
Abstract excerpt
Ovarian hyperandrogenism, a key feature of polycystic ovary syndrome, is preceded by precocious pubarche (PP) (pubic hair < 8 yr) in some populations. We hypothesized that this earlier presentation may relate to increased androgen sensitivity, indicated by androgen receptor gene CAG repeat length. This polymorphism was genotyped in 181 Barcelona girls (age, 10.9 yr; range, 4-19 yr) who had presented with PP, and...
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