Article
A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk.
Breast cancer research and treatment - 1 Oct 2008
Talbott Kathryn E, Gammon Marilie D, Kibriya Muhammad G, Chen Yu, Teitelbaum Susan L, Long Chang-Min, Gurvich Irina, Santella Regina M, Ahsan Habibul
Abstract excerpt
Due to the established association between estrogen levels and breast cancer risk, polymorphic variation in genes regulating estrogen levels is thought to be related to breast cancer risk. Aromatase, the protein product of the CYP19 gene, is involved in the production of endogenous estrogens via androgen conversion. We examined whether polymorphic variation in CYP19 associated with increased breast cancer risk in...
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