Article
Identification of an aromatase haplotype that is associated with gene expression and postmenopausal osteoporosis.
The Journal of clinical endocrinology and metabolism - 1 Feb 2007
Riancho José A, Valero Carmen, Naranjo Angel, Morales Dieter J, Sañudo Carolina, Zarrabeitia María T
Abstract excerpt
CONTEXT: Osteoporosis has a significant genetic component. The aromatase-dependent conversion of androgenic precursors is the main source of estrogens in postmenopausal women. OBJECTIVE: The objective of the investigation was to study the relationship of a set of single nucleotide polymorphisms (SNPs) of the aromatase gene with osteoporosis and determine their functional influence on gene transcription. DESIGN,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
